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Edibles now cover four biochemically distinct categories — cannabis edibles bind CB1 and CB2 receptors with 30-90 minute onset and 6-8 hour duration; adaptogens like ashwagandha modulate the HPA stress axis over weeks of daily use; Amanita muscaria acts through muscimol at GABA receptors for 4-10 hour dreamlike sedation; nootropics target dopamine and acetylcholine pathways. Formats span gummies, chocolates, baked goods, capsules, drinks, and hard candy — format itself affects onset speed.