Stoned

What Grayanotoxin Is and Why Mad Honey Produces a Different Effect Than Any Other Edible

Mad Honey is produced when Apis dorsata laboriosa — the world's largest honey bee — collects nectar from Rhododendron ponticum and R. luteum plants in the Himalayan highlands. Those plants concentrate grayanotoxins in their nectar as a natural defence compound. The bees transfer those compounds into the honey intact. Grayanotoxin binds to voltage-gated sodium channels in nerve cells, preventing them from completing their normal depolarisation cycle. That channel binding produces Mad Honey's signature effect: warmth spreading from the chest outward, mild euphoria, tingling in the extremities and a dreamy floating body calm. Onset 60 to 90 minutes. Peak 90 to 120 minutes. Duration 4 to 8 hours.

This receptor mechanism is entirely distinct from every other psychoactive compound in the Pro Cannabis catalogue. THC works through CB1 and CB2 endocannabinoid receptors. Psilocybin works through serotonin 5-HT2A receptors. Amanita muscimol works through GABA-A receptors. Grayanotoxin works through voltage-gated sodium channels — its own pathway, its own effect profile, no overlap with any of the others. The Stoned products contain no psilocybin. That is not a formulation choice — it is a compound category distinction. Mad Honey has never contained psilocybin.

Gurung Honey Hunters — The 2,500-Year Sourcing Tradition Behind Stoned's Nepal Mad Honey

The Gurung people of Nepal's Annapurna region have harvested wild honey from Himalayan cliff faces for generations — scaling sheer rock faces at 8,000 to 10,000 feet using hand-woven rope ladders to reach the combs of Apis dorsata laboriosa. The rhododendron bloom runs March to April. Honey harvested immediately after the bloom carries peak grayanotoxin concentration. Later harvests from the same combs carry lower levels as the compound metabolises in the hive. Stoned sources from spring harvest windows to capture peak-concentration material. What is in the Stoned edible is Nepalese rhododendron honey — not a synthesised grayanotoxin, not a botanical extract — standardised into an edible format with third-party lab verification per batch. This sourcing practice has 2,500 years of documented use in Nepal and Turkey as both traditional medicine and recreational substance.

Stoned Was First to Market With Mad Honey Gummies — What That Means for the Brand

Stoned Mushrooms Company launched their Mad Honey gummy line before competing brands entered the category — an early-mover position confirmed by independent retailers who note Stoned as the originator of this product format in the US hemp market. The brand's full catalogue at stonedmushrooms.com spans Mad Honey, Amanita Muscaria, Blue Lotus and THCA product lines — three distinct natural psychoactive botanical categories under one brand. Pro Cannabis carries the Mad Honey line. Per-batch third-party lab testing is published with potency and safety verification. Stoned products circulating without COA documentation at other retailers should be treated as authenticity-uncertain — the original brand publishes lab results per batch.

Gummy or Chocolate Bar — Two Formats, Same 800mg Formula, Different Sessions

• Mad Honey Nepal Gummies (10ct resealable, 10,000mg total): 800mg Mad Honey + 200mg hemp per gummy. Five fruit flavors: Apple, Cherry, Peach, Watermelon, Blue Raspberry. Gluten-free, pectin-based, all-natural colors. Resealable bag for multi-session portability. Half a gummy is the first-time starting dose — wait the full 90-minute onset window before any reassessment.
• Mad Honey Chocolate Bar (10 squares, 10,000mg total): 800mg Mad Honey per square. Five flavors: Milk Chocolate, Salted Caramel, Salted Pretzel, Birthday Cake, Cookies & Crème. Scored for precise per-square dosing. Made in USA — facility also processes soy, milk, wheat, peanuts, tree nuts and fish. One square is the standard starting dose.

Mad Honey Alongside Other Natural Psychoactive Edibles at Pro Cannabis

Mad Honey occupies one receptor pathway in the legal mushroom and nootropic edibles category at Pro Cannabis. TRE House Neurotonin™ mushroom gummies and chocolate bars use a proprietary nootropic blend — 5-HTP, Rhodiola Rosea and functional mushrooms — operating through serotonin and adaptogen pathways rather than sodium channels. Float Mushroom Delta-9 + Amanita edibles combine muscimol's GABA-A mechanism with Delta-9 THC for a cannabinoid layer Stoned's Mad Honey products do not carry. Buyers exploring nootropic chocolate formats will find the full range of natural psychoactive and functional edibles across the Pro Cannabis botanical wellness category.